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Cat No. | Product Name | Synonyms | Targets |
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T77494 | TNF-α-IN-9 | TNF | |
TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity. | |||
T19584L | TNF-α (31-45), human acetate | TNF-α (31-45), human acetate(144796-71-4 free base) | Others |
TNF-α (31-45), human acetate is a peptide of tumor necrosis factor-α. | |||
T36127 | TNF-α Antagonist | ||
TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact sit... | |||
T40321 | TNF-α-IN-6 | ||
TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM). | |||
T36097 | TNF-α-IN-2 | ||
TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in... | |||
T13175 | TNF-α-IN-1 | TNF | |
TNF-α-IN-1 is a TNF-α inhibitor. | |||
TP1626 | TNF-α (46-65), human | ||
Human TNF alpha (46-65) peptide. | |||
T19584 | TNF-α (31-45), human | Others | |
TNF-α (31-45), human is a peptide of tumor necrosis factor-α. | |||
TP1537 | TNF-α (10-36), human | ||
TNF-α (10-36), human is a potent pro-inflammatory cytokine involved in the acute phase stress response. | |||
T4637 | R-7050 | TNF-α Antagonist III | TNF |
R-7050 (TNF-α Antagonist III), a tumor necrosis factor receptor (TNFR) antagonist, exhibits heightened selectivity for TNFα. | |||
TP1636 | TNF-α (31-45), human TFA (144796-71-4 free base) | TNF-α (31-45), human TFA | |
TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α. | |||
TP1479 | TNF-α (10-36), human (TFA) (144796-70-3 free base) | TNF-α (10-36), human (TFA) | |
TNF-α (10-36), human (TFA) is a peptide of human TNF-α. | |||
TP1669 | TNF-α (46-65), human TFA (144796-72-5 free base) | TNF-α (46-65), human TFA | |
TNF-α (46-65), human (TFA) is a peptide of human TNF-α. | |||
T79025 | TNF-α-IN-10 | ||
TNF-α-IN-10 (compound 8a) acts as an inhibitor of IL-6 and TNF-α, demonstrating anti-inflammatory activity [1]. | |||
T78730 | TNF-α-IN-11 | ||
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM. By binding to TNF-α, it impedes TNF-α-induced caspase activation and the NF-κB signaling pathway. Additionally, it supp... | |||
T80973 | TNF-α-IN-8 | ||
TNF-α-IN-8 (compound I-42) is an isoindole-imide-based inhibitor of tumor necrosis factor-alpha (TNF-α) with applications in researching various diseases including cancer, heart disease, osteoporosis, and autoimmune diso... | |||
T8692 | (Rac)-Benpyrine | TNF | |
(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α. | |||
T8477 | IQ-3 | JNK | |
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α an... | |||
T7495 | Hexa-D-arginine | Others | |
Hexa-D-arginine is an inhibitor of furin,blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. | |||
T40423 | L48H37 | ||
L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interactio... | |||
T2343 | AS601245 | JNK | |
AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties. | |||
T8727 | TH1020 | TLR , Antibacterial | |
TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity. | |||
T76026 | TNF-α (31-45), human TFA | ||
TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α. Tumour necrosis factor alpha (TNF alpha) is an inflammatory cytokine that induces necrosis or apoptosis [1] . | |||
T13018 | SU3327 | halicin | JNK |
SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM). | |||
T8798 | MSA-2 | STING | |
MSA-2 is a potent and orally available non-nucleotide STING agonist. | |||
T22115 | SM-7368 | NF-κB | |
The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications. | |||
T4328 | OSS_128167 | SIRT6-IN-1 | HBV , Sirtuin |
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM). | |||
T6150 | TAK-715 | p38 MAPK , Casein Kinase , JNK | |
TAK-715 is a p38 MAPK inhibitor for p38α. | |||
T13324 | VUF11207 fumarate | CXCR , Arrestin | |
VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1). | |||
T3185 | R112 | (E)-Elafibranor | Syk |
R112 ((E)-Elafibranor) is an ATP-competitive inhibitor of Syk kinase. | |||
T22698 | TLR3-IN-1 | CU CPT 4a | TLR |
TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cell... | |||
T1781 | GW9508 | GW 9508 | GPR , Potassium Channel |
GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner. | |||
T6950 | PNU-120596 | NSC 216666 | AChR |
PNU-120596 (NSC-216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM. | |||
T6927 | Pamapimod | R1503,Ro4402257 | p38 MAPK , Autophagy |
Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectiv... | |||
T77778 | KP-457 | TNF‐α‐converting enzyme | |
KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17, with an IC50 value of 11.1 nM/L in cell-free assays. The compound can also cleave a variety of molecules, including GPIbα, GPV and TNF-α. | |||
T8505 | SC-236 | Sc 236 | Apoptosis , COX , PPAR |
SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively). | |||
T4403 | AX-024 hydrochloride | AX-024 HCl | IL Receptor , TNF , COX , IFNAR , Interleukin |
AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A. | |||
T2036 | 6-OAU | GTPL5846 | GPR |
6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay. | |||
T27695 | JTE-607 | JTE-607 dihydrochloride,JTE-607 HCl | Cysteine Protease |
JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. | |||
T3147 | Pyrrolidinedithiocarbamate ammonium | PDTC,Pyrrolidinedithiocarbamate,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate | NF-κB |
Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction. | |||
T6823 | E3330 | HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis | |
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. | |||
T4543 | Telithromycin | HMR3647,Ketek,RU66647 | Antibacterial , Antibiotic |
Telithromycin (HMR3647) is a ketolide antibiotic to treat community acquired pneumonia of mild to moderate severity. Antibacterial Telithromycin prevents bacteria from growing, by interfering with their protein synthesis... | |||
T14848 | C 87 | Others , TNF | |
C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities. | |||
T6204 | QNZ | CAY10470,EVP4593 | TNF , NF-κB |
QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively. | |||
T12985 | SPD304 dihydrochloride | TNF | |
SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers. | |||
T10730 | CDC801 | CDC-801 | TNF , PDE |
CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively. | |||
T4319 | Hispidol | (Z)-Hispidol | TNF |
Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM. | |||
T2384 | Pomalidomide | CC-4047 | Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues |
Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator. | |||
T2367 | SKF-86002 | SKF86002 | p38 MAPK , TNF |
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM). | |||
T22922 | Lenalidomide hemihydrate | TNF , Ligand for E3 Ligase , Molecular Glues | |
Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6S1572 | Sauchinone | ERK , p38 MAPK , NF-κB | |
1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative... | |||
T2893 | Muscone | 3-Methylcyclopentadecanone,Methylexaltone | MMP , TNF , NF-κB , NOD-like Receptor (NLR) , P-gp , Interleukin |
Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk. | |||
T15686 | L-741626 | 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole | Dopamine Receptor |
L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively). | |||
T2A2481 | Taurochenodeoxycholic Acid | Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine | Apoptosis , TNF , Caspase , Endogenous Metabolite |
Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. | |||
TN2130 | Manghaslin | Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside | AChE , Glucosidase |
Manghaslin (Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside) has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts. Manghaslin also shows inhibito... | |||
T2P2870 | Damascenone | trans-damascenone,Beta-Damascenone | Others , NF-κB , Endogenous Metabolite |
Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes. | |||
TN2215 | Taurochenodeoxycholic acid sodium | Sodium taurochenodeoxycholate | Apoptosis , Endogenous Metabolite |
Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and... | |||
T13808 | P-Coumaric Acid Ethyl Ester | Ethyl (E)-p-hydroxycinnamate,Ethyl trans-4-hydroxycinnamate | Others , Drug Metabolite |
p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate) is the ethyl ester of p-Coumaric acid. p-Coumaric Acid is a common dietary polyphenol and also a potent immunosuppressive agent in treating autoimmune inflammato... | |||
TCS2170 | 2,5-Dihydroxyacetophenone | Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP | ERK , NF-κB , Tyrosinase |
1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK... | |||
T5779 | MOSLOFLAVONE | IL Receptor , Virus Protease , TNF , Antibacterial | |
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively. | |||
TQ0218 | Deoxyandrographolide | 14-deoxyandrographolide | IL Receptor , TNF |
Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6. | |||
T3889 | Platycodin D | Prostaglandin Receptor , AMPK | |
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 1... | |||
TN2539 | 1beta-Hydroxyalantolactone | IL Receptor , TNF | |
1beta-Hydroxyalantolactone is a small molecular compound isolated from the flower head of the medicinal plant giant British flower, which can inhibit the expression of TNF-α, IL-17 and IFN-γ in cells, promote the secreti... | |||
T8288 | 14-Deoxyandrographolide | Apoptosis , Others | |
14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release. | |||
TC0036 | Compound Lup-20(29)-en-3-yl acetate | IL Receptor , VEGFR , Others , TNF , COX | |
Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B. | |||
T2720 | Ginsenoside Rc | Panaxoside Rc | Others , TNF , GABA Receptor , Interleukin |
Ginsenoside Rc (Panaxoside Rc) is one of the ginsenosides from Panax ginseng, inhibits the expression of TNF-α and IL-1β. | |||
T3887 | Rosarin | Others | |
Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice . | |||
T0131 | Cepharanthine | NSC-623442 | Apoptosis , TNF , HIV Protease , Autophagy |
Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and inhibits cytokine production. | |||
TN1520 | Isoforskolin | Coleonol B | IL Receptor , TNF |
Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used in studies about the treatment of Lyme arthritis. | |||
TN1507 | Clematichinenoside AR | TNF , Autophagy | |
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associated with collagen-induced arthritis. | |||
TN1511 | Cleomiscosin A | LDL , Antioxidant , TNF | |
Cleomiscosin A is derived from Acer okamotoanum leaf and twig and shows inhibitory activity to TNF-α secretion of the mouse peritoneal macrophages. Cleomiscosin A can be used in studies about the prevention of LDL oxidat... | |||
T13864 | Resolvin D1 | RvD1 | Apoptosis |
Resolvin D1 (RvD1) is an endogenous pro-inflammatory mediator that blocks pro-inflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α-mediated inflammation in macrophages, and enhances macroph... | |||
T3000 | Magnolol | NSC 293099,5,5'-Diallyl-2,2'-biphenyldiol | NF-κB , Retinoid Receptor , Antibacterial , PPAR , p53 , Autophagy |
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation. | |||
T5754 | Kavain | NF-κB , GABA Receptor | |
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of transcriptional factors such as NF-kB and LITAF. | |||
T2S0843 | Negletein | 7-O-Methylbaicalein,Baicalein-7-methylether | IL Receptor , TNF , NOS , Interleukin |
1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n... | |||
T5785 | MALTOTETRAOSE | Fujioligo 450,Amylotetraose,α-1,4-Tetraglucose | TNF , Endogenous Metabolite |
Maltotetraose (Fujioligo 450) are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression of early atherosclerosis development. | |||
TN6967 | (R)-Isomucronulatol | (-)-Isomucronulatol,2H-1-Benzopyran-7-ol | Apoptosis |
(R)-Isomucronulatol (2H-1-Benzopyran-7-ol), a flavonoid that can be extracted from the leaves of Astragalus membranaceus, Sophora japonica, Sclerotium tigrinum, and Glycyrrhiza glabra, inhibits the proliferation and apop... | |||
T6S1597 | Mulberroside A | TNF , Tyrosinase , Interleukin | |
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of... | |||
T3662 | Eleutheroside E | NF-κB | |
Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the ... | |||
T2759 | Loganin | Loganoside | Apoptosis , NF-κB , BACE , AChR , AChE |
Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent free-radical-scavenging activity and inhibitor... | |||
T6S2099 | Geraniin | Antioxidant , TNF | |
1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation ... | |||
T3816 | Velutin | NF-κB , HIF/HIF Prolyl-Hydroxylase | |
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ... | |||
TN1410 | Asperulosidic acid | ASPA | ERK , NF-κB |
Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-a... | |||
T3763 | Fumaric acid | Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,Donitic acid,Allomaleic acid | Endogenous Metabolite |
Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or a... | |||
T5S0167 | Atractylenolide I | IL Receptor , TNF , TLR , JAK , STAT | |
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide... | |||
T6S1579 | Monotropein | Monotropeine | Others |
1. Monotropein (Monotropeine) has antinociceptive action. 2. Monotropein has anti-apoptosis and anti-catabolic activity in chondrocytes. 3. Monotropein has anti-inflammatory action by inhibition of the expressions of inf... | |||
TN6694 | 5,6-Benzoflavone | β-Naphthoflavone,beta-NF | Antioxidant |
5,6-Benzoflavone (β-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (β-Naphthoflavone) possesses a... | |||
T4973 | Paraxanthine | 1,7-DIMETHYLXANTHINE | Endogenous Metabolite |
Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc... | |||
T2768 | Saikosaponin A | NF-κB , Antibacterial , Liver X Receptor | |
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath... | |||
T2758 | Madecassic acid | 6-Deoxy-L-Galactose,L-Fucose,Brahmic acid,L-fucopyranose | Others , TNF , COX , NO Synthase , Interleukin |
Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica. | |||
T2932 | Ginsenoside Rh1 | Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1 | IL Receptor , TNF , Endogenous Metabolite , PPAR , Interleukin |
Ginsenoside Rh1 (Sanchinoside B2) , one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect. | |||
T4S2063 | Tetrahydrocoptisine | STYLOPINE | ERK , p38 MAPK , NF-κB |
1. Tetrahydrocoptisine (STYLOPINE) has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibiting of NF-κB signaling pathways, which may invo... | |||
T6S0653 | Linarin | Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine | TNF , AChE |
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediat... | |||
T2794 | Astilbin | Neoastilbin,Taxifolin 3-O-rhamnoside,Isoastilbin,Taxifolin 3-rhamnoside,Neoisoastilbin | TNF , NF-κB , Nrf2 |
Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations. | |||
T3826 | Polygalasaponin F | NF-κB , TLR , Akt , PI3K | |
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po... | |||
T6S1495 | Ginsenoside Rk3 | Others , NF-κB | |
1. Ginsenoside Rk3 and Rh4 could have a role in treating inflammatory diseases. 2. Ginsenoside Rk3 is often used as a major ingredient of the compound preparation for ischemic heart diseases. | |||
T3240 | Citronellol | dihydrogeraniol,(±)-β-Citronellol | Reactive Oxygen Species |
Citronellol ((±)-β-Citronellol) is used in insect repellents and perfumes and as a mite attractant. | |||
T6S1049 | Wilforine | ATPase | |
Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis. Wilforine has anti-inflammatory effect, which might be medi... | |||
T6S0139 | Neobavaisoflavone | Apoptosis , DNA/RNA Synthesis | |
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si... | |||
T6S1538 | Neochlorogenic acid | trans-5-O-Caffeoylquinic acid,Neochlorogenate,5-O-Caffeoylquinic acid | TNF , NF-κB , COX , Antibacterial , Interleukin |
Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions. | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00779 | TNF alpha Protein, Rabbit, Recombinant | Rabbit | E. coli |
Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor ty... | |||
TMPY-04146 | TNF alpha Protein, Human, Recombinant (hFc) | Human | HEK293 |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-01294 | TNF alpha Protein, Mouse, Recombinant | Mouse | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-00936 | TNF alpha Protein, Human, Recombinant | Human | E. coli |
TNF alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375. | |||
TMPY-02202 | TNF alpha Protein, Rat, Recombinant | Rat | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-02153 | TNF beta Protein, Human, Recombinant | Human | E. coli |
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lympho... | |||
TMPK-00583 | TNF alpha Protein, Ferret, Recombinant (His) | Ferret | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, immune system developm... | |||
TMPK-00119 | TNF alpha Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, immune system developm... | |||
TMPK-00121 | TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, immune system developm... | |||
TMPK-00120 | TNF alpha Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, immune system developm... | |||
TMPJ-00124 | TNF alpha Protein, Human, Recombinant (aa 77-233, His) | Human | E. coli |
Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-α while cells that express CD8 secrete li... | |||
TMPJ-00125 | TNF alpha Protein, Human, Recombinant (aa 57-233, His) | Human | E. coli |
Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-α while cells that express CD8 secrete li... | |||
TMPJ-00288 | TNF RII Protein, Human, Recombinant (mFc) | Human | Human Cells |
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58% and 56% amino a... | |||
TMPY-05187 | TNF alpha Protein, Mouse, Recombinant, Biotinylated | Mouse | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPJ-00287 | TNF RII Protein, Human, Recombinant (hFc) | Human | Human Cells |
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58% and 56% amino a... | |||
TMPY-05237 | TNF alpha Protein, Human, Recombinant, Biotinylated | Human | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-02069 | TNF alpha Protein, Cynomolgus, Rhesus, Recombinant | Cynomolgus,Rhesus | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-01594 | TNF alpha Protein, Canine, Recombinant | Canine | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-05516 | TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated | Cynomolgus | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-02226 | TNF alpha Protein, Ferret, Recombinant | Ferret | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPJ-00546 | EFNA1 Protein, Human, Recombinant (hFc) | Human | Human Cells |
Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can ... | |||
TMPY-01750 | HVEM Protein, Human, Recombinant (His) | Human | HEK293 |
Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor sup... | |||
TMPY-01774 | TREM-1 Protein, Human, Recombinant (His) | Human | HEK293 |
TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growi... | |||
TMPY-01928 | IL-18 Protein, Rhesus, Recombinant (His) | Rhesus | E. coli |
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-g... | |||
TMPY-03273 | IL-18 Protein, Mouse, Recombinant | Mouse | E. coli |
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-g... | |||
TMPY-00277 | IL-18 Protein, Human, Recombinant | Human | E. coli |
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-g... | |||
TMPY-05053 | ANGPTL2 Protein, Human, Recombinant (His) | Human | HEK293 |
The angiopoietin-like protein (ANGPTL) family is homologous to angiopoietins but does not bind to the Tie2 receptor. The function of ANGPTLs has been elucidated largely in the context of angiogenesis and lipid metabolism... | |||
TMPJ-00619 | TNF RII Protein, Rhesus macaque, Recombinant (His) | Rhesus Macaque | Human Cells |
Tumor Necrosis Factor Receptor Superfamily Member 1B (TNFRSF1B) is a member of the Tumor Necrosis Factor Receptor Superfamily. TNFRSF1B contains four TNFR-Cys repeats. TNFRSF1B can be cleaved into the following 2 chains:... | |||
TMPJ-00618 | TNF RII Protein, Rhesus macaque, Recombinant (hFc) | Rhesus Macaque | Human Cells |
Tumor Necrosis Factor Receptor Superfamily Member 1B (TNFRSF1B) is a member of the Tumor Necrosis Factor Receptor Superfamily. TNFRSF1B contains four TNFR-Cys repeats. TNFRSF1B can be cleaved into the following 2 chains:... | |||
TMPJ-00296 | TNF RII Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | Human Cells |
Tumor Necrosis Factor Receptor Superfamily Member 1B (TNFRSF1B) is a member of the Tumor Necrosis Factor Receptor Superfamily. TNFRSF1B contains four TNFR-Cys repeats. TNFRSF1B can be cleaved into the following 2 chains:... | |||
TMPK-00564 | TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of... | |||
TMPJ-00968 | NAMPT Protein, Human, Recombinant (His) | Human | E. coli |
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular e... | |||
TMPK-01216 | SEMA7A Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Semaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain.Sema7A is upregulated in the epileptic brain and plays a potential role in the regulation of seizure activity in PTZ-kindled epileptic ra... | |||
TMPY-05380 | HVEM Protein, Human, Recombinant (hFc) | Human | HEK293 |
Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor sup... | |||
TMPY-04253 | HVEM Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor sup... | |||
TMPY-05417 | HVEM Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 |
Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor sup... | |||
TMPY-06941 | HVEM Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor sup... | |||
TMPY-05293 | HVEM Protein, Cynomolgus, Recombinant (His) | Cynomolgus | Baculovirus-Insect Cells |
Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor sup... | |||
TMPY-05515 | HVEM Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor sup... | |||
TMPY-02549 | GBP1 Protein, Human, Recombinant (His) | Human | HEK293 |
Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 ex... | |||
TMPK-00741 | SEMA7A Protein, Human, Recombinant (His) | Human | HEK293 |
Semaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain.Sema7A is upregulated in the epileptic brain and plays a potential role in the regulation of seizure activity in PTZ-kindled epileptic ra... | |||
TMPY-05512 | HVEM Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor sup... | |||
TMPY-01425 | HVEM Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 |
Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor sup... | |||
TMPY-03308 | ADAM17 Protein, Rat, Recombinant (His) | Rat | HEK293 |
ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative coliti... | |||
TMPJ-01105 | MPF Protein, Human, Recombinant (His) | Human | Human Cells |
Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura, pericardium, and peritoneum) and epithelial cells of the trachea, tonsils, fallopian tube, and kidneys. Me... | |||
TMPJ-00177 | BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated | Human | Human Cells |
B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), T... | |||
TMPJ-00680 | ANGPTL7 Protein, Human, Recombinant (His) | Human | Human Cells |
Angiopoietin-like 7 (ANGPTL7) is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain.... | |||
TMPJ-01104 | MPF Protein, Human, Recombinant (hFc) | Human | Human Cells |
Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura, pericardium, and peritoneum) and epithelial cells of the trachea, tonsils, fallopian tube, and kidneys. Me... | |||
TMPY-03861 | Amelotin Protein, Human, Recombinant (mFc) | Human | HEK293 |
Amelotin (AMTN) is a tooth enamel protein which is expressed in maturation-stage ameloblasts and also in the internal basal lamina of junctional epithelium, a unique epithelial structure attached to the tooth surface whi... | |||
TMPJ-01370 | EDAR Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
Ectodysplasin A receptor (EDAR) is a type I transmembrane protein of the TNF-α receptor superfamily which plays a key role in ectodermal differentiation. EDAR was encoded by the mouse downless gene and defective in human... | |||
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